Mrsa research papers

Mrsa articles 2018

We also briefly discuss another key part of MRSA infection management—prevention; however, an in depth discussion is beyond the scope of this review. This finding is similar to previous studies [34] , [44] , [48]. The virulent bacterium was first detected in hospitals and other health care facilities where vulnerable hosts, frequent exposure to the selective pressure of intensive antimicrobial therapy, and the necessity for invasive procedures created a favorable environment for dissemination. Further studies are necessary to elucidate these clinically important issues. Five of 28 Given the substantial morbidity and mortality associated with SAB [ 6 ] and the limitations of currently approved treatments, there is a need to identify alternative agents for the treatment of MRSA bacteremia. Differentiation of MRSA as a cause of pneumonia or merely colonization remains an important clinical issue and is of a particular interest in clinical settings. MRSA emerged as an important cause of health care-acquired infections, particularly central line-associated bloodstream infection, ventilator-associated pneumonia, and surgical site infection. Several issues restrict the utility of vancomycin, including slow bactericidal activity, low tissue penetration, and increasing reports of resistance and failure [ 9 , 10 , 11 ]. Nosocomial MRSA colonisations could not be completely prevented as we assumed health care workers were cohorted with the same patient for one day only. Daily changes to the health care worker roster and patient turnover resulted in changes to the makeup of each cohort. A statistical analysis revealed no positive relationship between the percentage of clones of the S.

MRSA is responsible for most global S. Given the substantial morbidity and mortality associated with SAB [ 6 ] and the limitations of currently approved treatments, there is a need to identify alternative agents for the treatment of MRSA bacteremia.

Community-acquired strains, including the USA strain, usually carry the gene for PVL, whereas it is rare in hospital-acquired strains [ 3037 ]. All S.

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MRSA methicillin-resistant S. Detected DNA sequences were then compared with those of the type strains using the basic local alignment search tool BLAST algorithm, as described previously. Physicians should carefully consider whether or not cultured MRSA is actually causative in each case because many patients fulfill these criteria and improve without anti-MRSA agents in real-world clinical settings.

Recent studies suggest colonization of the throat is more prevalent than of the nose, and checking only the nose would fail to detect a significant portion of colonized persons [ Current and developing diagnostic tools, treatments, and prevention strategies are also discussed.

Other studies identify chronic illness, injected drug use, recent hospitalization or outpatient visit, recent antibiotic use, and contact with an MRSA-infected person as risk factors.

Within a 1-year period — This review describes trends in epidemiology and factors that influence the incidence of MRSA bacteremia.

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MRSA Research Papers